Hepatobiliary & Pancreatic Surgery »  Meet the Team »  Surgical Oncology »  Eric Nakakura, M.D., Ph.D.

Eric Nakakura, M.D., Ph.D.

Professor of Surgery
Division of General Surgery

Contact Information

Academic Office
1600 Divisadero Street
Box 1932 | University of California, San Francisco
San Francisco, CA 94143-1932
Voice (415) 353-9294
Fax (415) 353-9695
eric.nakakura@ucsf.edu
Open Popup
  • 1986-90 University of California, San Diego B.S.  Bioengineering
  • 1990-95 Stanford University School of Medicine M.D.
  • 1995-96 Johns Hopkins Medical Institutions Intern  General Surgery
  • 1996-03 Johns Hopkins Medical Institutions Resident  General Surgery
  • 2001 John Radcliffe Hospital, Oxford University  General Surgery
  • 2003-04 Johns Hopkins Medical Institutions Fellow  Surgical Oncology
  • 1998-01 Johns Hopkins University Ph.D.  Cellular and Molecular Medicine
  • American Board of Surgery, 2004
  • GI Oncology Program
  • Member, UCSF Helen Diller Family Comprehensive Cancer Center
  • Surgical Oncology Laboratory
  • Sarcoma Program at UCSF
  • Concurrent EGFR and mTOR blockade in patients with pancreatic neuroendocrine tumors
  • Early detection of neuroendocrine tumors
  • Neuroendocrine (NE) tumors of the gastrointestinal (GI) Tract
  • Targeted therapy for treatment of neuroendocrine tumors
  • The role of proendocrine transcription factors and signaling pathways in normal and neoplastic gut
  • Translational studies of cancers of the pancreas and gastrointestinal tract

Dr. Eric Nakakura is a gastrointestinal cancer surgeon who specializes in tumors of the pancreas, bile ducts, liver, and GI tract. He also treats soft tissue sarcomas, including tumors of the retroperitoneum, trunk and extremities. Dr. Nakakura is a leading authority on neuroendocrine carcinoid tumors of the gastrointestinal tract and pancreas. In 2017, he was awarded a $1.2m grant from the Neuroendocrine Tumor Research Foundation (NETRF) to elucidate the causes of small intestinal neuroendocrine tumors (SI-NETs). 

Dr. Nakakura earned a medical degree at Stanford Medical School and a doctorate degree in cellular and molecular medicine at the Johns Hopkins University.  He completed a residency in general surgery at the Johns Hopkins Medical Institutions and was a specialist registrar in surgery at the John Radcliffe Hospital in Oxford, England. He also completed a fellowship in surgical oncology at the Johns Hopkins Medical Institutions.  

Neuroendocrine tumors (NETs) of the small intestine and pancreas frequently spread throughout the body (i.e., metastasize). Surgery is often not possible for patients with advanced disease, and current therapies are ineffective for shrinking tumors and durable palliation of debilitating symptoms, often caused by the release of hormones into the blood. Dr. Nakakura and his colleagues' long-term goal is to find the causes of NETs of the small intestine and pancreas, which can lead to earlier diagnosis and ultimately a cure.

How And Why Neuroendocrine Tumors Develop

In collaboration with Matthew Meyerson (Broad Institute, Dana-Farber Cancer Institute) and Chrissie Thirwell ( University College London Cancer Institute), Dr. Nakakura is studying the causes of small intestine neuroendocrine tumors utilizing state-of-the art genetic and epigenetic technologies of primary tumors and single cell analyses of precursor lesions. 

Funding: Neuroendocrine Tumor Research Foundation (NETRF) Accelerator Grant

Novel Neuroendocrine Tumor Models

A particular interest and focus of Dr. Nakakura's translational research is the development of novel neuroendocrine tumor models.  His laboratory successfully developed a patient-derived pancreatic neuroendocrine tumor (PNETs) xenograft model--the onlysuch model in the world--that faithfully retains the pathologic and genetic aberrations typical of human PNETs.  Dr. Nakakura's laboratory is collaborating with investigators worldwide, studying mechanisms of resistance to current therapies, novel small molecule targeted therapies, CAR T cell therapy, peptide receptor radionucleotide therapy, and the unfolded protein response. 

Funding: Neuroendocrine Tumor Research Foundation (NETRF), American Association for Cancer Research (AACR) 

Identification of Regulators of NET growth and Hormone Production

Dr. Nakakura's laboratory has a long-term interest to elucidate the transcriptional and signaling events critical to the pathogenesis of NETs of the small intestine and pancreas, which can identify novel targets for diagnosis and treatment. His approach has been to turn to developmental biology for clues.  Dr. Nakakura and collegues have found that the same transcription factors (Ascl1, Nkx2.2, Fev, Scratch)1-4 and signaling pathways (Notch)2 that function in the normal development of endocrine cells throughout the body also act to regulate NET hormone production and growth, as well as metastasis.  These findings that conserved pathways of neuroendocrine differentiation function in cancer have also shed important insight into normal gut endocrine cell development. 

Nakakura EK, Watkins DN, Schuebel KE, Sriuranpong V, Borges MW, Nelkin BD, Ball DW. Mammalian Scratch: a neural-specific Snail family transcriptional repressor. Proc Natl Acad Sci U S A, Mar/27/2001;98(7):4010-5. PMID: 11274425 

2  Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by Notch signaling. J Clin Endocrinol Metab, Jul/2005;90(7):4350-6.  PMID: 15870121  

3  Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocr Relat Cancer, Mar/2009;16(1):267-79.  PMID: 18987169 

4  Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK. The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine. Endocr Relat Cancer, 2010;17(1):283-91.  PMID: 20048018 

Neuroendocrine Tumors of Unknown Primary

Dr. Nakakura and colleagues have found a straightforward solution to a challenging issue for patients with NETs.  Often patients are diagnosed with a NET; however, the primary site remains elusive.  Based on the small size, submucosal location, and outward growth pattern of ileum NETs, they hypothesized that most patients with NET of unknown primary tumor have an ileal primary tumor.1  Indeed, despite a negative preoperative evaluation, surgical exploration identifies an ileal primary tumor in most cases.1-3  Their studies show that the routine use of many other tests, such as capsule endoscopy, enteroclysis, double-balloon enteroscopy, and endoscopic ultrasonography, is unnecessary because they will not affect patient care and will only delay treatment. 

Wang SC, Parekh JR, Zuraek MB, Venook AP, Bergsland EK, Warren RS, Nakakura EK. Identification of unknown primary tumors in patients with neuroendocrine liver metastases. Arch Surg. 2010 Mar; 145(3):276-80. PMID: 20231629 

Wang SC, Fidelman N, Nakakura EK. Management of well-differentiated gastrointestinal neuroendocrine tumors metastatic to the liver. Seminars in Oncology. 2013 Feb; 40(1):69-74. PMID 23391114

Bergsland EK, Nakakura EK. Neuroendocrine tumors of unknown primary: Is the primary site really not known? JAMA Surg. 2014 Sep; 149(9):889-90. PMID: 25029597

Predictors of Lymph Node Metastases in Pancreatic Neuroendocrine Tumors

The significance of lymph node metastases in PNETs is controversial. Consequently, the role and extent of lymph node sampling in PNETs is not standardized.  Therefore, there is no consensus regarding the optimal surgical approach for PNETs.  Surgical options include pancreas-preserving procedures (enucleation, central pancreatectomy) versus standard resections (pancreaticoduodenectomy, distal pancreatectomy). 

Dr. Nakakura and colleagues hypothesized that the conflicting prognostic value of PNET lymph node metastasis might be due to inadequate evaluations of lymph nodes and difficulties predicting metastasis.  They found that lymph nodes are not evaluated in many major pancreatic resections for PNET and preoperative prediction of nodal metastasis is difficult.1  Their findings suggest that enucleation of PNETs should be reserved for small insulinomas.  For other PNETs, surgeons should routinely sample lymph nodes, working closely with pathologists to maximize the number of lymph nodes identified in each specimen.  As a result of their study and that of others, the most recent NCCN guidelines for the management of PNETs have incorporated our recommendations and have affected patient management.2 

Parekh JR, Wang SC, Bergsland EK, Venook AP, Warren RS, Kim GE, Nakakura EK. Lymph Node Sampling Rates and Predictors of Nodal Metastasis in Pancreatic Neuroendocrine Tumor Resections: The UCSF Experience With 149 Patients. Pancreas. 2012 Aug; 41(6):840-4.  PMID: 22781907  

2  http://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf (login/password required)

Most recent publications from a total of 46
  1. Greene C, Nakakura EK, Ko AH. Gastrocutaneous Fistula in a Patient with Locally Recurrent MSI-High Colorectal Cancer: Local Complications Arising from Therapeutic Response to Immune Checkpoint Blockade. Anticancer Res. 2017 Jul; 37(7):3679-3684. View in PubMed
  2. Mulvey CK, Van Loon K, Bergsland EK, Masharani U, Nakakura EK. Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. Pancreas. 2017 Mar; 46(3):416-426. View in PubMed
  3. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596. View in PubMed
  4. Nakakura EK. Finding the Common Thread in Rare Diseases. JAMA Surg. 2016 Apr 1; 151(4):355. View in PubMed
  5. Hope TA, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK. Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging. EJNMMI Phys. 2015 Dec; 2(1):21. View in PubMed
  6. Yee AM, Kelly BG, Gonzalez-Velez JM, Nakakura EK. Solid pseudopapillary neoplasm of the pancreas head in a pregnant woman: safe pancreaticoduodenectomy postpartum. J Surg Case Rep. 2015; 2015(8). View in PubMed
  7. Hope TA, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E. Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor. Abdom Imaging. 2015 Aug; 40(6):1432-40. View in PubMed
  8. Walker EJ, Simko JP, Nakakura EK, Ko AH. A patient with cholangiocarcinoma demonstrating pathologic complete response to chemotherapy: exploring the role of neoadjuvant therapy in biliary tract cancer. J Gastrointest Oncol. 2014 Dec; 5(6):E88-95. View in PubMed
  9. Van Loon K, Zhang L, Keiser J, Carrasco C, Glass K, Ramirez MT, Bobiak S, Nakakura EK, Venook AP, Shah MH, Bergsland EK. Bone metastases and skeletal-related events from neuroendocrine tumors. Endocr Connect. 2015 Mar; 4(1):9-17. View in PubMed
  10. Bergsland EK, Nakakura EK. Neuroendocrine tumors of unknown primary: is the primary site really not known? JAMA Surg. 2014 Sep; 149(9):889-90. View in PubMed
  11. View All Publications
Publications provided by UCSF Profiles, powered by CTSI at UCSF. View profile of Eric Nakakura, M.D., Ph.D.
Please note: UCSF Profiles publications are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact CTSI for help.

X